Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease Xander H.T. Wehrens

ISBN: 9781280190230

Published: March 20th 2006

ebook

330 pages


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Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease  by  Xander H.T. Wehrens

Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease by Xander H.T. Wehrens
March 20th 2006 | ebook | PDF, EPUB, FB2, DjVu, audiobook, mp3, RTF | 330 pages | ISBN: 9781280190230 | 7.68 Mb

Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from theMoreDrs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology.

The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias.

The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions. David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical School



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